Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974)

AIMS: To evaluate inhibition of capsaicin-induced increase in dermal blood flow (DBF) following telcagepant (MK-0974), a potent and selective orally bioavailable calcitonin gene-related peptide (CGRP) receptor antagonist being developed for the acute treatment of migraine. METHODS: A three-period cr...

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Detalhes bibliográficos
Main Authors: Sinclair, Simon R, Kane, Stefanie A, Van der Schueren, Bart J, Xiao, Alan, Willson, Kenneth J, Boyle, Janet, de Lepeleire, Inge, Xu, Yang, Hickey, Lisa, Denney, William S, Li, Chi-Chung, Palcza, John, Vanmolkot, Floris H M, Depré, Marleen, Van Hecken, Anne, Murphy, M Gail, Ho, Tony W, de Hoon, Jay N
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830593/
https://ncbi.nlm.nih.gov/pubmed/20078608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03543.x
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