Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

The nuclear receptor retinoid-related orphan receptor gamma t (RORγt) plays a critical role in driving Th17 cell differentiation and expansion, as well as IL-17 production in innate and adaptive immune cells. The IL-23/IL-17 axis is implicated in several autoimmune and inflammatory diseases, and bio...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Xue, Xiaohua, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Castro, Glenda, Albers, Michael, Schoetens, Freddy, DePrimo, Samuel, Devineni, Damayanthi, Wilde, Thomas, Goldberg, Steve, Kinzel, Olaf, Hoffmann, Thomas, Fourie, Anne M., Thurmond, Robin L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155022/
https://ncbi.nlm.nih.gov/pubmed/34040108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90497-9
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky