Improved Ca(v)2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide

[Image: see text] We report the investigation of sulfonamide-derived Ca(v)2.2 inhibitors to address drug-metabolism liabilities with this lead class of analgesics. Modification of the benzamide substituent provided improvements in both potency and selectivity. However, we discovered that formation o...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2013
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027232/
https://ncbi.nlm.nih.gov/pubmed/24900606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4002612
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla