Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

[Image: see text] A new subseries of ROMK inhibitors exemplified by 28 has been developed from the initial screening hit 1. The excellent selectivity for ROMK inhibition over related ion channels and pharmacokinetic properties across preclinical species support further preclinical evaluation of 28 a...

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Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T., Swensen, Andrew M., Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass, Adam, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Pai, Lee-Yuh, Corona, Aaron, Hampton, Caryn, Hernandez, Melba, Bentley, Ross, Chen, Jing, Shah, Kashmira, Metzger, Joseph, Forrest, Michael, Owens, Karen, Tong, Vincent, Ha, Sookhee, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Parmee, Emma, Garcia, Maria L., Sullivan, Kathleen, Pasternak, Alexander
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499836/
https://ncbi.nlm.nih.gov/pubmed/26191360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500440u
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