GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

av Miller, Corin, Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Bunzel, Michelle, Cao, Jin, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam B., Li, Xiaoyan, Myers, Robert W., Knagge, Kevin, Carrington, Paul E., Hagmann, William K., Trujillo, Maria E.
I publikationen PLoS One (2017)

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics

av Tang, Haifeng, Walsh, Shawn P., Yan, Yan, de Jesus, Reynalda K., Shahripour, Aurash, Teumelsan, Nardos, Zhu, Yuping, Ha, Sookhee, Owens, Karen A., Thomas-Fowlkes, Brande S., Felix, John P., Liu, Jessica, Kohler, Martin, Priest, Birgit T., Bailey, Timothy, Brochu, Richard, Alonso-Galicia, Magdalena, Kaczorowski, Gregory J., Roy, Sophie, Yang, Lihu, Mills, Sander G., Garcia, Maria L., Pasternak, Alexander
Publicerad 2012

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure

av Tang, Haifeng, Zhu, Yuping, Teumelsan, Nardos, Walsh, Shawn P., Shahripour, Aurash, Priest, Birgit T., Swensen, Andrew M., Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Pai, Lee-Yuh, Hampton, Caryn, Corona, Aaron, Hernandez, Melba, Metzger, Joseph, Forrest, Michael, Zhou, Xiaoyan, Owens, Karen, Tong, Vincent, Parmee, Emma, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Alonso-Galicia, Magdalena, Garcia, Maria L., Pasternak, Alexander
I publikationen ACS Med Chem Lett (2016)

GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent

av Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Cheewatrakoolpong, Boonlert, Xue, Jiyan, Szeto, Daphne, Forrest, Gail, Miller, Corin, Bunzel, Michelle, Plummer, Christopher W., Chobanian, Harry R., Miller, Michael W., Souza, Sarah, Thomas-Fowlkes, Brande S., Ogawa, Aimie M., Weinglass, Adam B., Di Salvo, Jerry, Li, Xiaoyan, Feng, Yue, Tatosian, Daniel A., Howard, Andrew D., Colletti, Steven L., Trujillo, Maria E.
I publikationen PLoS One (2017)

Structure–Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs

av Chen, Helen Y., Plummer, Christopher W., Xiao, Dong, Chobanian, Harry R., DeMong, Duane, Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Souza, Sarah, Tatosian, Daniel A., Chen, Qing, Hafey, Michael J., Houle, Robert, Nolting, Andrew F., Orr, Robert, Ehrhart, Juliann, Weinglass, Adam B., Tschirret-Guth, Richard, Howard, Andrew D., Colletti, Steven L.
I publikationen ACS Med Chem Lett (2018)

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

av Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T., Swensen, Andrew M., Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass, Adam, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Pai, Lee-Yuh, Corona, Aaron, Hampton, Caryn, Hernandez, Melba, Bentley, Ross, Chen, Jing, Shah, Kashmira, Metzger, Joseph, Forrest, Michael, Owens, Karen, Tong, Vincent, Ha, Sookhee, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Parmee, Emma, Garcia, Maria L., Sullivan, Kathleen, Pasternak, Alexander
I publikationen ACS Med Chem Lett (2015)

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

av Cox, Jason M., Chu, Hong D., Chelliah, Mariappan V., Debenham, John S., Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A., Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M., Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R., Crespo, Alejandro, Madeira, Maria, Leung, Dennis H., Alleyne, Candice, Ogawa, Aimie M., Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
I publikationen ACS Med Chem Lett (2016)