Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine

The multiple transmembrane protein Niemann-Pick C1 like1 (NPC1L1) is essential for intestinal cholesterol absorption. Ezetimibe binds to NPC1L1 and is a clinically used cholesterol absorption inhibitor. Recent studies in cultured cells have shown that NPC1L1 mediates cholesterol uptake through vesic...

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Huvudupphovsmän: Xie 谢畅, Chang, Zhou 周章森, Zhang-Sen, Li 李钠, Na, Bian 卞艳, Yan, Wang 王永建, Yong-Jian, Wang 王丽娟, Li-Juan, Li 李伯良, Bo-Liang, Song 宋保亮, Bao-Liang
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435542/
https://ncbi.nlm.nih.gov/pubmed/22811412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M027359
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