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Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine
The multiple transmembrane protein Niemann-Pick C1 like1 (NPC1L1) is essential for intestinal cholesterol absorption. Ezetimibe binds to NPC1L1 and is a clinically used cholesterol absorption inhibitor. Recent studies in cultured cells have shown that NPC1L1 mediates cholesterol uptake through vesic...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Biochemistry and Molecular Biology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435542/ https://ncbi.nlm.nih.gov/pubmed/22811412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M027359 |
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