GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy

GPR40 and GPR120 are fatty acid sensors that play important roles in glucose and energy homeostasis. GPR40 potentiates glucose-dependent insulin secretion and demonstrated in clinical studies robust glucose lowering in type 2 diabetes. GPR120 improves insulin sensitivity in rodents, albeit its mecha...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Satapati, Santhosh, Qian, Ying, Wu, Margaret S., Petrov, Aleksandr, Dai, Ge, Wang, Sheng-ping, Zhu, Yonghua, Shen, Xiaolan, Muise, Eric S., Chen, Ying, Zycband, Emanuel, Weinglass, Adam, Di Salvo, Jerry, Debenham, John S., Cox, Jason M., Lan, Ping, Shah, Vinit, Previs, Stephen F., Erion, Mark, Kelley, David E., Wang, Liangsu, Howard, Andrew D., Shang, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538279/
https://ncbi.nlm.nih.gov/pubmed/28583918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M075044
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