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Activation of peroxisome proliferator-activated receptor γ (PPARγ) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation

Nitroalkene fatty acids are potent endogenous ligand activators of PPARγ-dependent transcription. Previous studies with the naturally occurring regioisomers of nitrolinoleic acid revealed that the isomers are not equivalent with respect to PPARγ activation. To gain further insight into the structure...

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Detalhes bibliográficos
Main Authors: Gorczynski, Michael J., Smitherman, Pamela K., Akiyama, Taro E., Wood, Harold B., Berger, Joel P., King, S. Bruce, Morrow, Charles S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741172/
https://ncbi.nlm.nih.gov/pubmed/19719236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900326c
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