Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux

Disruption of the peroxisome proliferator-activated receptor γ (PPARγ) gene causes embryonic lethality due to placental dysfunction. To circumvent this, a PPARγ conditional gene knockout mouse was produced by using the Cre-loxP system. The targeted allele, containing loxP sites flanking exon 2 of th...

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Autori principali: Akiyama, Taro E., Sakai, Shuichi, Lambert, Gilles, Nicol, Christopher J., Matsusue, Kimihiko, Pimprale, Satish, Lee, Ying-Hue, Ricote, Mercedes, Glass, Christopher K., Brewer, H. Bryan, Gonzalez, Frank J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC133709/
https://ncbi.nlm.nih.gov/pubmed/11909955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2607-2619.2002
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