Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents

[Image: see text] GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A selective activator of GPR120 containing a chromane scaffold has been designed, synthesized, and evaluated in vivo. Results of...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Adams, Gregory L., Velazquez, Francisco, Jayne, Charles, Shah, Unmesh, Miao, Shouwu, Ashley, Eric R., Madeira, Maria, Akiyama, Taro E., Di Salvo, Jerry, Suzuki, Takao, Wang, Nengxue, Truong, Quang, Gilbert, Eric, Zhou, Dan, Verras, Andreas, Kirkland, Melissa, Pachanski, Michele, Powles, Maryann, Yin, Wu, Ujjainwalla, Feroze, Venkatraman, Srikanth, Edmondson, Scott D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2016
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238488/
https://ncbi.nlm.nih.gov/pubmed/28105282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00394
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