Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination

[Image: see text] GPR40 is a G-protein-coupled receptor which mediates fatty acid-induced glucose-stimulated insulin secretion from pancreatic beta cells and incretion release from enteroendocrine cells of the small intestine. GPR40 full agonists exhibit superior glucose lowering compared to partial...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Huang, Hui, Meegalla, Sanath K., Lanter, James C., Winters, Michael P., Zhao, Shuyuan, Littrell, James, Qi, Jenson, Rady, Brian, Lee, Paul S., Liu, Jianying, Martin, Tonya, Lam, Wing W., Xu, Fran, Lim, Heng Keang, Wilde, Thomas, Silva, Jose, Otieno, Monicah, Pocai, Alessandro, Player, Mark R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2018
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331191/
https://ncbi.nlm.nih.gov/pubmed/30655940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00444
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