Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes

Por Wu, Wen-Lian, Hao, Jinsong, Domalski, Martin, Burnett, Duane A., Pissarnitski, Dmitri, Zhao, Zhiqiang, Stamford, Andrew, Scapin, Giovanna, Gao, Ying-Duo, Soriano, Aileen, Kelly, Terri M., Yao, Zuliang, Powles, Mary Ann, Chen, Shiying, Mei, Hong, Hwa, Joyce
Publicado no ACS Med Chem Lett (2016)

CNS Amyloid-β, Soluble APP-α and -β Kinetics during BACE Inhibition

Por Dobrowolska, Justyna A., Michener, Maria S., Wu, Guoxin, Patterson, Bruce W., Chott, Robert, Ovod, Vitaliy, Pyatkivskyy, Yuriy, Wildsmith, Kristin R., Kasten, Tom, Mathers, Parker, Dancho, Mandy, Lennox, Christina, Smith, Brad E., Gilberto, David, McLoughlin, Debra, Holder, Daniel J., Stamford, Andrew W., Yarasheski, Kevin E., Kennedy, Matthew E., Savage, Mary J., Bateman, Randall J.
Publicado em 2014

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Por Stamford, Andrew W., Scott, Jack D., Li, Sarah W., Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N., Gilbert, Eric J., Huang, Chunli, McKittrick, Brian A., Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H., Kennedy, Matthew E., Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Parker, Eric M., Greenlee, William J.
Publicado em 2012

Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

Por Liu, Ping, Hu, Zhiyong, DuBois, Byron G., Moyes, Christopher R., Hunter, David N., Zhu, Cheng, Kar, Nam Fung, Zhu, Yuping, Garfunkle, Joie, Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Lamberson, Joe, Ujjainwalla, Fez, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.
Publicado no ACS Med Chem Lett (2015)

Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors

Por Bungard, Christopher J., Williams, Peter D., Schulz, Jurgen, Wiscount, Catherine M., Holloway, M. Katharine, Loughran, H. Marie, Manikowski, Jesse J., Su, Hua-Poo, Bennett, David J., Chang, Lehua, Chu, Xin-Jie, Crespo, Alejandro, Dwyer, Michael P., Keertikar, Kartik, Morriello, Gregori J., Stamford, Andrew W., Waddell, Sherman T., Zhong, Bin, Hu, Bin, Ji, Tao, Diamond, Tracy L., Bahnck-Teets, Carolyn, Carroll, Steven S., Fay, John F., Min, Xu, Morris, William, Ballard, Jeanine E., Miller, Michael D., McCauley, John A.
Publicado no ACS Med Chem Lett (2017)