Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPP(swe) Mice Without Inducing Microhemorrhage

Por Villarreal, Stephanie, Zhao, Fuqiang, Hyde, Lynn A., Holder, Daniel, Forest, Thomas, Sondey, Marie, Chen, Xia, Sur, Cyrille, Parker, Eric M., Kennedy, Matthew E.
Publicado no J Alzheimers Dis (2017)

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

Por Zhao, Zhiqiang, Pissarnitski, Dmitri A., Huang, Xianhai, Palani, Anandan, Zhu, Zhaoning, Greenlee, William J., Hyde, Lynn A., Song, Lixin, Terracina, Giuseppe, Zhang, Lili, Parker, Eric M.
Publicado no ACS Med Chem Lett (2017)

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Por Hyde, Lynn A., Zhang, Qi, Del Vecchio, Robert A., Leach, Prescott T., Cohen-Williams, Mary E., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.
Publicado em 2013

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Por Wu, Wen-Lian, Domalski, Martin, Burnett, Duane A., Josien, Hubert, Bara, Thomas, Rajagopalan, Murali, Xu, Ruo, Clader, John, Greenlee, William J., Brunskill, Andrew, Hyde, Lynn A., Del Vecchio, Robert A., Cohen-Williams, Mary E., Song, Lixin, Lee, Julie, Terracina, Giuseppe, Zhang, Qi, Nomeir, Amin, Parker, Eric M., Zhang, Lili
Publicado em 2012

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Por Stamford, Andrew W., Scott, Jack D., Li, Sarah W., Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N., Gilbert, Eric J., Huang, Chunli, McKittrick, Brian A., Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H., Kennedy, Matthew E., Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Parker, Eric M., Greenlee, William J.
Publicado em 2012