Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

[Image: see text] The design and synthesis of a new series of tetrahydrobenzisoxazoles as modulators of γ-secretase activity and their structure–activity relationship (SAR) will be detailed. Several compounds are active γ-secretase modulators (GSMs) with good to excellent selectivity for the reducti...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Zhao, Zhiqiang, Pissarnitski, Dmitri A., Huang, Xianhai, Palani, Anandan, Zhu, Zhaoning, Greenlee, William J., Hyde, Lynn A., Song, Lixin, Terracina, Giuseppe, Zhang, Lili, Parker, Eric M.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641957/
https://ncbi.nlm.nih.gov/pubmed/29057041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00178
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