The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

[Image: see text] A series of novel pyridazone and pyridone compounds as γ-secretase modulators were discovered. Starting from the initial lead, structure−activity relationship studies were carried out in which an internal hydrogen bond was introduced to conformationally fix the side chain, and comp...

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Bibliografiske detaljer
Main Authors: Huang, Xianhai, Aslanian, Robert, Zhou, Wei, Zhu, Xiaohong, Qin, Jun, Greenlee, William, Zhu, Zhaoning, Zhang, Lili, Hyde, Lynn, Chu, Inhou, Cohen-Williams, Mary, Palani, Anandan
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2010
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007853/
https://ncbi.nlm.nih.gov/pubmed/24900193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000799
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