Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

[Image: see text] The synthesis and structure−activity relationship of a novel series of pyrazolopyridines are reported. These compounds represent a new class of γ-secretase modulators that demonstrate good in vitro potency in inhibiting Aβ(42) production. Examples with statistically significant in...

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Autors principals: Qin, Jun, Zhou, Wei, Huang, Xianhai, Dhondi, Pawan, Palani, Anandan, Aslanian, Robert, Zhu, Zhaoning, Greenlee, William, Cohen-Williams, Mary, Jones, Nicholas, Hyde, Lynn, Zhang, Lili
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2011
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018171/
https://ncbi.nlm.nih.gov/pubmed/24900332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2000438
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