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Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes
[Image: see text] We report herein the design and synthesis of a series of potent and selective GPR119 agonists. Our objective was to develop a GPR119 agonist with properties that were suitable for fixed-dose combination with a DPP4 inhibitor. Starting from a phenoxy analogue (1), medicinal chemistr...
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| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2015
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538435/ https://ncbi.nlm.nih.gov/pubmed/26288697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00207 |
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