Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

[Image: see text] We report herein the design and synthesis of a series of potent and selective GPR119 agonists. Our objective was to develop a GPR119 agonist with properties that were suitable for fixed-dose combination with a DPP4 inhibitor. Starting from a phenoxy analogue (1), medicinal chemistr...

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出版年:ACS Med Chem Lett
主要な著者: Liu, Ping, Hu, Zhiyong, DuBois, Byron G., Moyes, Christopher R., Hunter, David N., Zhu, Cheng, Kar, Nam Fung, Zhu, Yuping, Garfunkle, Joie, Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Lamberson, Joe, Ujjainwalla, Fez, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2015
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538435/
https://ncbi.nlm.nih.gov/pubmed/26288697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00207
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