Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

[Image: see text] We report herein the design and synthesis of a series of potent and selective GPR119 agonists. Our objective was to develop a GPR119 agonist with properties that were suitable for fixed-dose combination with a DPP4 inhibitor. Starting from a phenoxy analogue (1), medicinal chemistr...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Liu, Ping, Hu, Zhiyong, DuBois, Byron G., Moyes, Christopher R., Hunter, David N., Zhu, Cheng, Kar, Nam Fung, Zhu, Yuping, Garfunkle, Joie, Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Lamberson, Joe, Ujjainwalla, Fez, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538435/
https://ncbi.nlm.nih.gov/pubmed/26288697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00207
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