Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

[Image: see text] We report herein the design and synthesis of a series of potent and selective GPR119 agonists. Our objective was to develop a GPR119 agonist with properties that were suitable for fixed-dose combination with a DPP4 inhibitor. Starting from a phenoxy analogue (1), medicinal chemistr...

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Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Liu, Ping, Hu, Zhiyong, DuBois, Byron G., Moyes, Christopher R., Hunter, David N., Zhu, Cheng, Kar, Nam Fung, Zhu, Yuping, Garfunkle, Joie, Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Lamberson, Joe, Ujjainwalla, Fez, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538435/
https://ncbi.nlm.nih.gov/pubmed/26288697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00207
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