Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

[Image: see text] We report herein the design and synthesis of a series of potent and selective GPR119 agonists. Our objective was to develop a GPR119 agonist with properties that were suitable for fixed-dose combination with a DPP4 inhibitor. Starting from a phenoxy analogue (1), medicinal chemistr...

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Opis bibliograficzny
Wydane w:ACS Med Chem Lett
Główni autorzy: Liu, Ping, Hu, Zhiyong, DuBois, Byron G., Moyes, Christopher R., Hunter, David N., Zhu, Cheng, Kar, Nam Fung, Zhu, Yuping, Garfunkle, Joie, Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Lamberson, Joe, Ujjainwalla, Fez, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2015
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538435/
https://ncbi.nlm.nih.gov/pubmed/26288697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00207
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