Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

[Image: see text] Extensive structure–activity relationship studies of a series derived from atropisomer 1, a previously described chiral benzodiazepine sulfonamide series, led to a potent, brain penetrant and selective compound with excellent preclinical pharmacokinetic across species. We also desc...

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Główni autorzy: Chobanian, Harry R., Guo, Yan, Liu, Ping, Chioda, Marc, Lanza, Thomas J., Chang, Linda, Kelly, Theresa M., Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J., Metzger, Joseph M., Gorski, Judith N., Raustad, Kate, Wang, Sheng-Ping, Strack, Alison M., Miller, Randy, Pang, Jianmei, Madeira, Maria, Lyons, Kathy, Dragovic, Jasminka, Reitman, Marc L., Nargund, Ravi P., Lin, Linus S.
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2012
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025675/
https://ncbi.nlm.nih.gov/pubmed/24900461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200304j
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