Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality

[Image: see text] We report herein the discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 (BRS-3) agonists and their unusual chirality. Starting from a high-throughput screening lead, we prepared a series of BRS-3 agonists with improved potency and pharmacokinetic properties,...

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Detalhes bibliográficos
Main Authors: Liu, Ping, Lanza, Thomas J., Chioda, Marc, Jones, Carrie, Chobanian, Harry R., Guo, Yan, Chang, Linda, Kelly, Theresa M., Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J., Metzger, Joseph M., Ramsay, Katie, Wang, Sheng-Ping, Strack, Alison M., Miller, Randy, Pang, Jianmei, Lyons, Kathy, Dragovic, Jasminka, Ning, Jian G., Schafer, Wes A., Welch, Christopher J., Gong, Xiaoyi, Gao, Ying-Duo, Hornak, Viktor, Ball, Richard G., Tsou, Nancy, Reitman, Marc L., Wyvratt, Matthew J., Nargund, Ravi P., Lin, Linus S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017983/
https://ncbi.nlm.nih.gov/pubmed/24900283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200207w
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