Interactions of Human Melanocortin 4 Receptor with Non Peptide and Peptide Agonists

Specific interactions of human melanocortin-4 receptor (hMC4R) with its non-peptide and peptide agonists were studied using alanine-scanning mutagenesis. The binding affinities and potencies of two synthetic small-molecule agonists (THIQ, MB243) were strongly affected by substitutions in transmembra...

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Detalhes bibliográficos
Main Authors: Pogozheva, Irina D., Chai, Biao-Xin, Lomize, Andrei L., Fong, Tung M., Weinberg, David H., Nargund, Ravi P., Mulholland, Michael W., Gantz, Ira, Mosberg, Henry I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532597/
https://ncbi.nlm.nih.gov/pubmed/16114870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0501840
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