Homing in on genomic instability as a therapeutic target in cancer

nork Bielski, Craig M., Taylor, Barry S.
Argitaratua izan da Nat Commun (2021)

Genetic effect of chemotherapy exposure in children of testicular cancer survivors

nork Kryukov, Gregory V., Bielski, Craig M., Samocha, Kaitlin, Fromer, Menachem, Seepo, Sara, Gentry, Carleen, Neale, Benjamin, Garraway, Levi A., Sweeney, Christopher, Taplin, Mary-Ellen, Van Allen, Eliezer M.
Argitaratua izan da Clin Cancer Res (2015)

EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer

nork Oldrini, Barbara, Hsieh, Wan-Ying, Erdjument-Bromage, Hediye, Codega, Paolo, Carro, Maria Stella, Curiel-García, Alvaro, Campos, Carl, Pourmaleki, Maryam, Grommes, Christian, Vivanco, Igor, Rohle, Daniel, Bielski, Craig M., Taylor, Barry S., Hollmann, Travis J., Rosenblum, Marc, Tempst, Paul, Blenis, John, Squatrito, Massimo, Mellinghoff, Ingo K.
Argitaratua izan da Nat Commun (2017)

Phase and context shape the function of composite oncogenic mutations

nork Gorelick, Alexander N., Sánchez-Rivera, Francisco J., Cai, Yanyan, Bielski, Craig M., Biederstedt, Evan, Jonsson, Philip, Richards, Allison L., Vasan, Neil, Penson, Alexander V., Friedman, Noah D., Ho, Yu-Jui, Baslan, Timour, Bandlamudi, Chaitanya, Scaltriti, Maurizio, Schultz, Nikolaus, Lowe, Scott W., Reznik, Ed, Taylor, Barry S.
Argitaratua izan da Nature (2020)

Genome doubling shapes the evolution and prognosis of advanced cancers

nork Bielski, Craig M., Zehir, Ahmet, Penson, Alexander V., Donoghue, Mark T.A., Chatila, Walid, Armenia, Joshua, Chang, Matthew T., Schram, Alison M., Jonsson, Philip, Bandlamudi, Chaitanya, Razavi, Pedram, Iyer, Gopa, Robson, Mark E., Stadler, Zsofia K., Schultz, Nikolaus, Baselga, Jose, Solit, David B., Hyman, David M., Berger, Michael F., Taylor, Barry S.
Argitaratua izan da Nat Genet (2018)

Widespread selection for oncogenic mutant allele imbalance in cancer

nork Bielski, Craig M., Donoghue, Mark T.A., Gadiya, Mayur, Hanrahan, Aphrothiti J., Won, Helen H., Chang, Matthew T., Jonsson, Philip, Penson, Alexander V., Gorelick, Alexander, Harris, Christopher, Schram, Alison M., Syed, Aijazuddin, Zehir, Ahmet, Chapman, Paul B., Hyman, David M., Solit, David B., Shannon, Kevin, Chandarlapaty, Sarat, Berger, Michael F., Taylor, Barry S.
Argitaratua izan da Cancer Cell (2018)

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence In Cancer

nork Burgess, Michael R., Hwang, Eugene, Mroue, Rana, Bielski, Craig M., Wandler, Anica M., Huang, Benjamin, Firestone, Ari J., Young, Amy, LaCap, Jennifer A., Crocker, Lisa, Asthana, Saurabh, Davis, Elizabeth M., Xu, Jin, Akagi, Keiko, Le Beau, Michelle M., Li, Qing, Haley, Ben, Stokoe, David, Sampath, Deepak, Taylor, Barry S., Evangelista, Marie, Shannon, Kevin
Argitaratua izan da Cell (2017)

MTAP deletion confers enhanced dependency on the arginine methyltransferase PRMT5 in human cancer cells

nork Kryukov, Gregory V, Wilson, Frederick H, Ruth, Jason R, Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E, Vazquez, Francisca, Weir, Barbara A, Fitzgerald, Mark E, Tanaka, Minoru, Bielski, Craig M, Scott, Justin M, Dennis, Courtney, Cowley, Glenn S, Boehm, Jesse S, Root, David E, Golub, Todd R, Clish, Clary B, Bradner, James E, Hahn, William C, Garraway, Levi A
Argitaratua izan da Science (2016)

The genetic evolution of treatment-resistant cutaneous, acral and uveal melanomas

nork Makohon-Moore, Alvin P., Lipson, Evan J., Hooper, Jody E., Zucker, Amanda, Hong, Jungeui, Bielski, Craig M., Hayashi, Akimasa, Tokheim, Collin, Baez, Priscilla, Kappagantula, Rajya, Kohutek, Zachary, Makarov, Vladimir, Riaz, Nadeem, Postow, Michael A., Chapman, Paul B., Karchin, Rachel, Socci, Nicholas D., Solit, David B., Chan, Timothy A., Taylor, Barry, Topalian, Suzanne L., Iacobuzio-Donahue, Christine A.
Argitaratua izan da Clin Cancer Res (2020)

The Evolutionary Origins of Recurrent Pancreatic Cancer

nork Sakamoto, Hitomi, Attiyeh, Marc A., Gerold, Jeffrey M., Makohon-Moore, Alvin P., Hayashi, Akimasa, Hong, Jungeui, Kappagantula, Rajya, Zhang, Lance, Melchor, Jerry P., Reiter, Johannes G., Heyde, Alexander, Bielski, Craig M., Penson, Alexander V., Gönen, Mithat, Chakravarti, Debyani, O’Reilly, Eileen M., Wood, Laura D., Hruban, Ralph H., Nowak, Martin A., Socci, Nicholas D., Taylor, Barry S., Iacobuzio-Donahue, Christine A.
Argitaratua izan da Cancer Discov (2020)

Opposing effects of cancer type-specific SPOP mutations on BET protein degradation and sensitivity to BET inhibitors

nork Janouskova, Hana, Tekle, Geniver El, Bellini, Elisa, Udeshi, Namrata D., Rinaldi, Anna, Ulbricht, Anna, Bernasocchi, Tiziano, Civenni, Gianluca, Losa, Marco, Svinkina, Tanya, Bielski, Craig M., Kryukov, Gregory V., Cascione, Luciano, Napoli, Sara, Enchev, Radoslav I., Mutch, David G., Carney, Michael E., Berchuck, Andrew, Winterhoff, Boris J.N., Broaddus, Russell R., Schraml, Peter, Moch, Holger, Bertoni, Francesco, Catapano, Carlo V., Peter, Matthias, Carr, Steven A., Garraway, Levi A., Wild, Peter J., Theurillat, Jean-Philippe P.
Argitaratua izan da Nat Med (2017)

Tumor lineage shapes BRCA-mediated phenotypes

nork Jonsson, Philip, Bandlamudi, Chaitanya, Cheng, Michael L., Srinivasan, Preethi, Chavan, Shweta S., Friedman, Noah D., Rosen, Ezra Y., Richards, Allison L., Bouvier, Nancy, Selcuklu, S. Duygu, Bielski, Craig M., Abida, Wassim, Mandelker, Diana, Birsoy, Ozge, Zhang, Liying, Zehir, Ahmet, Donoghue, Mark T.A., Baselga, José, Offit, Kenneth, Scher, Howard I., O’Reilly, Eileen M., Stadler, Zsofia K., Schultz, Nikolaus, Socci, Nicholas D., Viale, Agnes, Ladanyi, Marc, Robson, Mark E., Hyman, David M., Berger, Michael F., Solit, David B., Taylor, Barry S.
Argitaratua izan da Nature (2019)

Germ Cell Tumor Molecular Heterogeneity Revealed Through Analysis of Primary and Metastasis Pairs

nork Cheng, Michael L., Donoghue, Mark T.A., Audenet, François, Wong, Nathan C., Pietzak, Eugene J., Bielski, Craig M., Isharwal, Sumit, Iyer, Gopa, Funt, Samuel, Bagrodia, Aditya, Bajorin, Dean F., Reuter, Victor E., Eng, Jana, Joseph, Gabriella, Bourque, Caitlin, Bromberg, Maria, Ling, Lilan, Selcuklu, S. Duygu, Arcila, Maria E., Tsui, Dana W.Y., Zehir, Ahmet, Viale, Agnes, Berger, Michael F., Bosl, George J., Sheinfeld, Joel, Van Allen, Eliezer, Taylor, Barry S., Al-Ahmadie, Hikmat, Solit, David B., Feldman, Darren R.
Argitaratua izan da JCO Precis Oncol (2020)

Accelerating discovery of functional mutant alleles in cancer

nork Chang, Matthew T., Bhattarai, Tripti Shrestha, Schram, Alison M., Bielski, Craig M., Donoghue, Mark T.A., Jonsson, Philip, Chakravarty, Debyani, Phillips, Sarah, Kandoth, Cyriac, Penson, Alexander, Gorelick, Alexander, Shamu, Tambudzai, Patel, Swati, Harris, Christopher, Gao, JianJiong, Sumer, Selcuk Onur, Kundra, Ritika, Razavi, Pedram, Li, Bob T., Reales, Dalicia N., Socci, Nicholas D., Jayakumaran, Gowtham, Zehir, Ahmet, Benayed, Ryma, Arcila, Maria E, Chandarlapaty, Sarat, Ladanyi, Marc, Schultz, Nikolaus, Baselga, Jose, Berger, Michael F., Rosen, Neal, Solit, David B., Hyman, David M., Taylor, Barry S.
Argitaratua izan da Cancer Discov (2017)

Integrated genetic and pharmacologic interrogation of rare cancers

nork Hong, Andrew L., Tseng, Yuen-Yi, Cowley, Glenn S., Jonas, Oliver, Cheah, Jaime H., Kynnap, Bryan D., Doshi, Mihir B., Oh, Coyin, Meyer, Stephanie C., Church, Alanna J., Gill, Shubhroz, Bielski, Craig M., Keskula, Paula, Imamovic, Alma, Howell, Sara, Kryukov, Gregory V., Clemons, Paul A., Tsherniak, Aviad, Vazquez, Francisca, Crompton, Brian D., Shamji, Alykhan F., Rodriguez-Galindo, Carlos, Janeway, Katherine A., Roberts, Charles W. M., Stegmaier, Kimberly, van Hummelen, Paul, Cima, Michael J., Langer, Robert S., Garraway, Levi A., Schreiber, Stuart L., Root, David E., Hahn, William C., Boehm, Jesse S.
Argitaratua izan da Nat Commun (2016)

The long tail of oncogenic drivers in prostate cancer

nork Armenia, Joshua, Wankowicz, Stephanie A.M., Liu, David, Gao, Jianjiong, Kundra, Ritika, Reznik, Ed, Chatila, Walid K., Chakravarty, Debyani, Han, G. Celine, Coleman, Ilsa, Montgomery, Bruce, Pritchard, Colin, Morrissey, Colm, Barbieri, Christopher E., Beltran, Himisha, Sboner, Andrea, Zafeiriou, Zafeiris, Miranda, Susana, Bielski, Craig M., Penson, Alexander V., Tolonen, Charlotte, Huang, Franklin W., Robinson, Dan, Wu, Yi Mi, Lonigro, Robert, Garraway, Levi A., Demichelis, Francesca, Kantoff, Philip W., Taplin, Mary-Ellen, Abida, Wassim, Taylor, Barry S., Scher, Howard I., Nelson, Peter S., de Bono, Johann S., Rubin, Mark A., Sawyers, Charles L., Chinnaiyan, Arul M., Schultz, Nikolaus, Van Allen, Eliezer M.
Argitaratua izan da Nat Genet (2018)

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

nork Razavi, Pedram, Chang, Matthew T., Xu, Guotai, Bandlamudi, Chaitanya, Ross, Dara S., Vasan, Neil, Cai, Yanyan, Bielski, Craig M., Donoghue, Mark T.A., Jonsson, Philip, Penson, Alexander, Shen, Ronglai, Pareja, Fresia, Kundra, Ritika, Middha, Sumit, Cheng, Michael L., Zehir, Ahmet, Kandoth, Cyriac, Patel, Ruchi, Huberman, Kety, Smyth, Lillian M., Jhaveri, Komal, Modi, Shanu, Traina, Tiffany A., Dang, Chau, Zhang, Wen, Weigelt, Britta, Li, Bob T., Ladanyi, Marc, Hyman, David M., Schultz, Nikolaus, Robson, Mark E., Hudis, Clifford, Brogi, Edi, Viale, Agnes, Norton, Larry, Dickler, Maura N., Berger, Michael F., Iacobuzio-Donahue, Christine A., Chandarlapaty, Sarat, Scaltriti, Maurizio, Reis-Filho, Jorge S., Solit, David B., Taylor, Barry S., Baselga, José
Argitaratua izan da Cancer Cell (2018)

Next-generation characterization of the Cancer Cell Line Encyclopedia

nork Ghandi, Mahmoud, Huang, Franklin W., Jané-Valbuena, Judit, Kryukov, Gregory V., Lo, Christopher C., McDonald, E. Robert, Barretina, Jordi, Gelfand, Ellen T., Bielski, Craig M., Li, Haoxin, Hu, Kevin, Andreev-Drakhlin, Alexander Y., Kim, Jaegil, Hess, Julian M., Haas, Brian J., Aguet, François, Weir, Barbara A., Rothberg, Michael V., Paolella, Brenton R., Lawrence, Michael S., Akbani, Rehan, Lu, Yiling, Tiv, Hong L., Gokhale, Prafulla C., de Weck, Antoine, Mansour, Ali Amin, Oh, Coyin, Shih, Juliann, Hadi, Kevin, Rosen, Yanay, Bistline, Jonathan, Venkatesan, Kavitha, Reddy, Anupama, Sonkin, Dmitriy, Liu, Manway, Lehar, Joseph, Korn, Joshua M, Porter, Dale A., Jones, Michael D., Golji, Javad, Caponigro, Giordano, Taylor, Jordan E., Dunning, Caitlin M., Creech, Amanda L., Warren, Allison C., McFarland, James M., Zamanighomi, Mahdi, Kauffmann, Audrey, Stransky, Nicolas, Imielinski, Marcin, Maruvka, Yosef E., Cherniack, Andrew D., Tsherniak, Aviad, Vazquez, Francisca, Jaffe, Jacob D., Lane, Andrew A., Weinstock, David M., Johannessen, Cory M., Morrissey, Michael P., Stegmeier, Frank, Schlegel, Robert, Hahn, William C., Getz, Gad, Mills, Gordon B., Boehm, Jesse S., Golub, Todd R., Garraway, Levi A., Sellers, William R.
Argitaratua izan da Nature (2019)