Opposing effects of cancer type-specific SPOP mutations on BET protein degradation and sensitivity to BET inhibitors

It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified recurrent but divergent missense mutations in the substrate recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostate canc...

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Publicado no:Nat Med
Main Authors: Janouskova, Hana, Tekle, Geniver El, Bellini, Elisa, Udeshi, Namrata D., Rinaldi, Anna, Ulbricht, Anna, Bernasocchi, Tiziano, Civenni, Gianluca, Losa, Marco, Svinkina, Tanya, Bielski, Craig M., Kryukov, Gregory V., Cascione, Luciano, Napoli, Sara, Enchev, Radoslav I., Mutch, David G., Carney, Michael E., Berchuck, Andrew, Winterhoff, Boris J.N., Broaddus, Russell R., Schraml, Peter, Moch, Holger, Bertoni, Francesco, Catapano, Carlo V., Peter, Matthias, Carr, Steven A., Garraway, Levi A., Wild, Peter J., Theurillat, Jean-Philippe P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592092/
https://ncbi.nlm.nih.gov/pubmed/28805821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4372
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