Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer

Driver genes with a mutually exclusive mutation pattern across tumor genomes are thought to have overlapping roles in tumorigenesis. In contrast, we show here that mutually exclusive prostate cancer driver alterations involving the ERG transcription factor and the ubiquitin ligase adaptor SPOP are s...

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Publicado no:Nat Commun
Main Authors: Bernasocchi, Tiziano, El Tekle, Geniver, Bolis, Marco, Mutti, Azzurra, Vallerga, Arianna, Brandt, Laura P., Spriano, Filippo, Svinkina, Tanya, Zoma, Marita, Ceserani, Valentina, Rinaldi, Anna, Janouskova, Hana, Bossi, Daniela, Cavalli, Manuela, Mosole, Simone, Geiger, Roger, Dong, Ze, Yang, Cai-Guang, Albino, Domenico, Rinaldi, Andrea, Schraml, Peter, Linder, Simon, Carbone, Giuseppina M., Alimonti, Andrea, Bertoni, Francesco, Moch, Holger, Carr, Steven A., Zwart, Wilbert, Kruithof-de Julio, Marianna, Rubin, Mark A., Udeshi, Namrata D., Theurillat, Jean-Philippe P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854732/
https://ncbi.nlm.nih.gov/pubmed/33531470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20820-x
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