Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer

Driver genes with a mutually exclusive mutation pattern across tumor genomes are thought to have overlapping roles in tumorigenesis. In contrast, we show here that mutually exclusive prostate cancer driver alterations involving the ERG transcription factor and the ubiquitin ligase adaptor SPOP are s...

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Publicat a:Nat Commun
Autors principals: Bernasocchi, Tiziano, El Tekle, Geniver, Bolis, Marco, Mutti, Azzurra, Vallerga, Arianna, Brandt, Laura P., Spriano, Filippo, Svinkina, Tanya, Zoma, Marita, Ceserani, Valentina, Rinaldi, Anna, Janouskova, Hana, Bossi, Daniela, Cavalli, Manuela, Mosole, Simone, Geiger, Roger, Dong, Ze, Yang, Cai-Guang, Albino, Domenico, Rinaldi, Andrea, Schraml, Peter, Linder, Simon, Carbone, Giuseppina M., Alimonti, Andrea, Bertoni, Francesco, Moch, Holger, Carr, Steven A., Zwart, Wilbert, Kruithof-de Julio, Marianna, Rubin, Mark A., Udeshi, Namrata D., Theurillat, Jean-Philippe P.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854732/
https://ncbi.nlm.nih.gov/pubmed/33531470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20820-x
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