Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

The bromodomain and extra-terminal (BET) family of proteins, comprised of four members including BRD2, BRD3, BRD4 and the testis-specific isoform BRDT, largely function as transcriptional co-activators (1–3) and play critical roles in various cellular processes, including cell cycle, apoptosis, migr...

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Publicado no:Nat Med
Main Authors: Dai, Xiangpeng, Gan, Wenjian, Li, Xiaoning, Wang, Shangqian, Zhang, Wei, Huang, Ling, Liu, Shengwu, Zhong, Qing, Guo, Jianping, Zhang, Jinfang, Chen, Ting, Shimizu, Kouhei, Beca, Francisco, Blattner, Mirjam, Vasudevan, Divya, Buckley, Dennis L., Qi, Jun, Buser, Lorenz, Liu, Pengda, Inuzuka, Hiroyuki, Beck, Andrew H., Wang, Liewei, Wild, Peter J., Garraway, Levi A., Rubin, Mark A., Barbieri, Christopher E., Wong, Kwok-Kin, Muthuswamy, Senthil K., Huang, Jiaoti, Chen, Yu, Bradner, James E., Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625299/
https://ncbi.nlm.nih.gov/pubmed/28805820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4378
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