SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression

Frequent SPOP mutation defines the molecular feature underlying one of seven sub-types of human prostate cancer (PrCa). However, it remains largely elusive how SPOP functions as a tumor suppressor in PrCa. Here, we report that SPOP suppresses stem cell traits of both embryonic stem cells and PrCa ce...

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Pubblicato in:Dev Cell
Autori principali: Zhang, Jinfang, Chen, Ming, Zhu, Yasheng, Dai, Xiangpeng, Dang, Fabin, Ren, Junming, Ren, Shancheng, Shulga, Yulia V., Beca, Francisco, Gan, Wenjian, Wu, Fei, Lin, Yu-Min, Zhou, Xiaobo, DeCaprio, James A., Beck, Andrew H., Lu, Kun Ping, Huang, Jiaoti, Zhao, Cheryl, Sun, Yinghao, Gao, Xu, Pandolfi, Pier Paolo, Wei, Wenyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462403/
https://ncbi.nlm.nih.gov/pubmed/30595538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.11.035
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