Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation

Recent studies revealed that mutations in SPOP (Speckle-type POZ protein) occur in up to 15% of patients with prostate cancer. However, the physiological role of SPOP in regulating prostate tumorigenesis remains elusive. Here, we identified the Cdc20 oncoprotein as a novel ubiquitin substrate of SPO...

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Pubblicato in:Cancer Lett
Autori principali: Wu, Fei, Dai, Xiangpeng, Gan, Wenjian, Wan, Lixin, Li, Min, Mitsiades, Nicholas, Wei, Wenyi, Ding, Qiang, Zhang, Jinfang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148662/
https://ncbi.nlm.nih.gov/pubmed/27780719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2016.10.021
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