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Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells
EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-in...
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| Publicado no: | Cancer Lett |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5511705/ https://ncbi.nlm.nih.gov/pubmed/28089830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.01.003 |
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