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Cullin 3(SPOP) ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6
The histone deacetylase 6 (HDAC6) plays critical roles in human tumorigenesis and metastasis. As such, HDAC6-selective inhibitors have entered clinical trials for cancer therapy. However, the upstream regulator(s), especially ubiquitin E3 ligase(s), responsible for controlling the protein stability...
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| Veröffentlicht in: | Oncotarget |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Impact Journals LLC
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5564613/ https://ncbi.nlm.nih.gov/pubmed/28599312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18141 |
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