SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa) resulting in its overexpression. However, whether this is the sole mechanism underlying ERG elevation in PrCa is currently unclear. Here we report that ERG ubiquitination and degradation is governed by the Cullin 3-base...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Gan, Wenjian, Dai, Xiangpeng, Lunardi, Andrea, Li, Zhen, Inuzuka, Hiroyuki, Liu, Pengda, Varmeh, Shoreh, Zhang, Jinfang, Cheng, Liang, Sun, Yin, Asara, John M., Beck, Andrew H., Huang, Jiaoti, Pandolfi, Pier Paolo, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575912/
https://ncbi.nlm.nih.gov/pubmed/26344095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.07.026
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