Opposing effects of cancer type-specific SPOP mutations on BET protein degradation and sensitivity to BET inhibitors

It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified recurrent but divergent missense mutations in the substrate recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostate canc...

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Библиографические подробности
Опубликовано в: :Nat Med
Главные авторы: Janouskova, Hana, Tekle, Geniver El, Bellini, Elisa, Udeshi, Namrata D., Rinaldi, Anna, Ulbricht, Anna, Bernasocchi, Tiziano, Civenni, Gianluca, Losa, Marco, Svinkina, Tanya, Bielski, Craig M., Kryukov, Gregory V., Cascione, Luciano, Napoli, Sara, Enchev, Radoslav I., Mutch, David G., Carney, Michael E., Berchuck, Andrew, Winterhoff, Boris J.N., Broaddus, Russell R., Schraml, Peter, Moch, Holger, Bertoni, Francesco, Catapano, Carlo V., Peter, Matthias, Carr, Steven A., Garraway, Levi A., Wild, Peter J., Theurillat, Jean-Philippe P.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592092/
https://ncbi.nlm.nih.gov/pubmed/28805821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4372
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