V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer

מאת Gao, Yijun, Maria, Ann, Na, Na, Paula, Arnaud da Cruz, Gorelick, Alexander N., Hechtman, Jaclyn F., Carson, Julianne, Lefkowitz, Robert A., Weigelt, Britta, Taylor, Barry S., Zhao, HuiYong, Reis-Filho, Jorge S., de Stanchina, Elisa, Rosen, Neal, Yao, Zhan, Yaeger, Rona
הוצא לאור ב Cancer Discov (2019)

Phase and context shape the function of composite oncogenic mutations

מאת Gorelick, Alexander N., Sánchez-Rivera, Francisco J., Cai, Yanyan, Bielski, Craig M., Biederstedt, Evan, Jonsson, Philip, Richards, Allison L., Vasan, Neil, Penson, Alexander V., Friedman, Noah D., Ho, Yu-Jui, Baslan, Timour, Bandlamudi, Chaitanya, Scaltriti, Maurizio, Schultz, Nikolaus, Lowe, Scott W., Reznik, Ed, Taylor, Barry S.
הוצא לאור ב Nature (2020)

Putative Drivers of Aggressiveness in TCEB1-mutant Renal Cell Carcinoma: An Emerging Entity with Variable Clinical Course

מאת DiNatale, Renzo G., Gorelick, Alexander N., Makarov, Vladimir, Blum, Kyle A., Silagy, Andrew W., Freeman, Benjamin, Chowell, Diego, Marcon, Julian, Mano, Roy, Sanchez, Alex, Attalla, Kyrollis, Weng, Stanley, Voss, Martin, Motzer, Robert J., Russo, Paul, Coleman, Jonathan, Reuter, Victor E., Chen, Ying-Bei, Chan, Timothy A., Reznik, Ed, Tickoo, Satish K., Hakimi, A. Ari
הוצא לאור ב Eur Urol Focus (2019)

Altered nuclear export signal recognition as a driver of oncogenesis

מאת Taylor, Justin, Sendino, Maria, Gorelick, Alexander N., Pastore, Alessandro, Chang, Matthew T., Penson, Alexander V., Gavrila, Elena I., Stewart, Connor, Melnik, Ella M., Chavez, Florisela Herrejon, Bitner, Lillian, Yoshimi, Akihide, Lee, Stanley Chun-wei, Inoue, Daichi, Liu, Bo, Zhang, Xiao J., Mato, Anthony R., Dogan, Ahmet, Kharas, Michael G., Chen, Yuhong, Wang, Demin, Soni, Rajesh K., Hendrickson, Ronald C., Prieto, Gorka, Rodriguez, Jose A., Taylor, Barry S., Abdel-Wahab, Omar
הוצא לאור ב Cancer Discov (2019)

Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer

מאת Hanrahan, Aphrothiti J., Sylvester, Brooke E., Chang, Matthew T., Elzein, Arijh, Gao, JianJiong, Han, Weiwei, Liu, Ye, Xu, Dong, Gao, Sizhi P., Gorelick, Alexander N., Jones, Alexis M., Kiliti, Amber J., Nissan, Moriah H., Nimura, Clare A., Poteshman, Abigail N., Yao, Zhan, Gao, Yijun, Hu, Wenhuo, Wise, Hannah C., Gavrila, Elena I., Shoushtari, Alexander N., Tiwari, Shakuntala, Viale, Agnes, Abdel-Wahab, Omar, Merghoub, Taha, Berger, Michael F., Rosen, Neal, Taylor, Barry S., Solit, David B.
הוצא לאור ב Cancer Res (2020)

TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors

מאת Cocco, Emiliano, Lee, Ji Eun, Kannan, Srinivasaraghavan, Schram, Alison M, Won, Helen H, Shifman, Sophie, Kulick, Amanda, Baldino, Laura, Toska, Eneda, Arruabarrena-Aristorena, Amaia, Kittane, Srushti, Wu, Fan, Cai, Yanyan, Arena, Sabrina, Mussolin, Benedetta, Kannan, Ram, Vasan, Neil, Gorelick, Alexander N., Berger, Michael F, Novoplansky, Ofra, Jagadeeshan, Sankar, Liao, Yi, Rix, Uwe, Misale, Sandra, Taylor, Barry S, Bardelli, Alberto, Hechtman, Jaclyn F, Hyman, David M, Elkabets, Moshe, de Stanchina, Elisa, Verma, Chandra S, Ventura, Andrea, Drilon, Alexander, Scaltriti, Maurizio
הוצא לאור ב Cancer Discov (2020)

Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer

מאת Smyth, Lillian M., Piha-Paul, Sarina A., Won, Helen, Schram, Alison M., Saura, Cristina, Loi, Sherene, Lu, Janice, Shapiro, Geoffrey I., Juric, Dejan, Mayer, Ingrid A., Arteaga, Carlos L., de la Fuente, Macarena I., Brufksy, Adam M., Spanggaard, Iben, Mau-Sørensen, Morten, Arnedos, Monica, Moreno, Victor, Boni, Valentina, Sohn, Joohyuk, Schwartzberg, Lee S., Gonzàlez-Farré, Xavier, Cervantes, Andrés, Bidard, François-Clement, Gorelick, Alexander N., Lanman, Richard B., Nagy, Rebecca J., Ulaner, Gary A., Chandarlapaty, Sarat, Jhaveri, Komal, Gavrila, Elena I., Zimel, Catherine, Selcuklu, S. Duygu, Melcer, Myra, Samoila, Aliaksandra, Cai, Yanyan, Scaltriti, Maurizio, Mann, Grace, Xu, Feng, Eli, Lisa D., Dujka, Melanie, Lalani, Alshad S., Bryce, Richard, Baselga, José, Taylor, Barry S., Solit, David B., Meric-Bernstam, Funda, Hyman, David M.
הוצא לאור ב Cancer Discov (2019)