Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer

Despite significant advances in cancer precision medicine, a significant hurdle to its broader adoption remains the multitude of variants of unknown significance identified by clinical tumor sequencing and the lack of biologically validated methods to distinguish between functional and benign varian...

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Publicado en:Cancer Res
Main Authors: Hanrahan, Aphrothiti J., Sylvester, Brooke E., Chang, Matthew T., Elzein, Arijh, Gao, JianJiong, Han, Weiwei, Liu, Ye, Xu, Dong, Gao, Sizhi P., Gorelick, Alexander N., Jones, Alexis M., Kiliti, Amber J., Nissan, Moriah H., Nimura, Clare A., Poteshman, Abigail N., Yao, Zhan, Gao, Yijun, Hu, Wenhuo, Wise, Hannah C., Gavrila, Elena I., Shoushtari, Alexander N., Tiwari, Shakuntala, Viale, Agnes, Abdel-Wahab, Omar, Merghoub, Taha, Berger, Michael F., Rosen, Neal, Taylor, Barry S., Solit, David B.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541597/
https://ncbi.nlm.nih.gov/pubmed/32641410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0865
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