3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

Many mutations in cancer are of unknown functional significance. Standard methods use statistically significant recurrence of mutations in tumor samples as an indicator of functional impact. We extend such analyses into the long tail of rare mutations by considering recurrence of mutations in cluste...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Gao, Jianjiong, Chang, Matthew T., Johnsen, Hannah C., Gao, Sizhi Paul, Sylvester, Brooke E., Sumer, Selcuk Onur, Zhang, Hongxin, Solit, David B., Taylor, Barry S., Schultz, Nikolaus, Sander, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260099/
https://ncbi.nlm.nih.gov/pubmed/28115009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0393-x
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