Altered nuclear export signal recognition as a driver of oncogenesis

Altered expression of XPO1, the main nuclear export receptor in eukaryotic cells, has been observed in cancer and XPO1 has been a focus of anti-cancer drug development. However, mechanistic evidence for cancer-specific alterations in XPO1 function is lacking. Here, genomic analysis of 42,793 cancers...

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Publicat a:Cancer Discov
Autors principals: Taylor, Justin, Sendino, Maria, Gorelick, Alexander N., Pastore, Alessandro, Chang, Matthew T., Penson, Alexander V., Gavrila, Elena I., Stewart, Connor, Melnik, Ella M., Chavez, Florisela Herrejon, Bitner, Lillian, Yoshimi, Akihide, Lee, Stanley Chun-wei, Inoue, Daichi, Liu, Bo, Zhang, Xiao J., Mato, Anthony R., Dogan, Ahmet, Kharas, Michael G., Chen, Yuhong, Wang, Demin, Soni, Rajesh K., Hendrickson, Ronald C., Prieto, Gorka, Rodriguez, Jose A., Taylor, Barry S., Abdel-Wahab, Omar
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774834/
https://ncbi.nlm.nih.gov/pubmed/31285298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0298
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