Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex

por Xie, Wei, Wang, Shengliu, Wang, Juncheng, de la Cruz, M. Jason, Xu, Guotai, Scaltriti, Maurizio, Patel, Dinshaw J.
Publicado en Proc Natl Acad Sci U S A (2021)

Proteomics of Genetically Engineered Mouse Mammary Tumors Identifies Fatty Acid Metabolism Members as Potential Predictive Markers for Cisplatin Resistance

por Warmoes, Marc, Jaspers, Janneke E., Xu, Guotai, Sampadi, Bharath K., Pham, Thang V., Knol, Jaco C., Piersma, Sander R., Boven, Epie, Jonkers, Jos, Rottenberg, Sven, Jimenez, Connie R.
Publicado 2013

CopywriteR: DNA copy number detection from off-target sequence data

por Kuilman, Thomas, Velds, Arno, Kemper, Kristel, Ranzani, Marco, Bombardelli, Lorenzo, Hoogstraat, Marlous, Nevedomskaya, Ekaterina, Xu, Guotai, de Ruiter, Julian, Lolkema, Martijn P, Ylstra, Bauke, Jonkers, Jos, Rottenberg, Sven, Wessels, Lodewyk F, Adams, David J, Peeper, Daniel S, Krijgsman, Oscar
Publicado en Genome Biol (2015)

PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

por Toska, Eneda, Castel, Pau, Chhangawala, Sagar, Arruabarrena-Aristorena, Amaia, Chan, Carmen, Hristidis, Vasilis C., Cocco, Emiliano, Sallaku, Mirna, Xu, Guotai, Park, Jane, Minuesa, Gerard, Shifman, Sophie G., Socci, Nicholas D., Koche, Richard, Leslie, Christina S., Scaltriti, Maurizio, Baselga, José
Publicado en Cell Rep (2019)

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt‐based anti‐cancer drugs

por Planells‐Cases, Rosa, Lutter, Darius, Guyader, Charlotte, Gerhards, Nora M, Ullrich, Florian, Elger, Deborah A, Kucukosmanoglu, Asli, Xu, Guotai, Voss, Felizia K, Reincke, S Momsen, Stauber, Tobias, Blomen, Vincent A, Vis, Daniel J, Wessels, Lodewyk F, Brummelkamp, Thijn R, Borst, Piet, Rottenberg, Sven, Jentsch, Thomas J
Publicado en EMBO J (2015)

Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors

por Cai, Yanyan, Xu, Guotai, Wu, Fan, Michelini, Flavia, Chan, Carmen, Qu, Xuan, Selenica, Pier, Ladewig, Erik, Castel, Pau, Cheng, Yuanming, Zhao, Alison, Jhaveri, Komal, Toska, Eneda, Jimenez, Marta, Jacquet, Alexandra, Tran-Dien, Alicia, Andre, Fabrice, Chandarlapaty, Sarat, Reis-Filho, Jorge S., Razavi, Pedram, Scaltriti, Maurizio
Publicado en Cancer Res (2021)

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

por Vasan, Neil, Razavi, Pedram, Johnson, Jared L., Shao, Hong, Shah, Hardik, Antoine, Alesia, Ladewig, Erik, Gorelick, Alexander, Lin, Ting-Yu, Toska, Eneda, Xu, Guotai, Kazmi, Abiha, Chang, Matthew T., Taylor, Barry S., Dickler, Maura N., Jhaveri, Komal, Chandarlapaty, Sarat, Rabadan, Raul, Reznik, Ed, Smith, Melissa L., Sebra, Robert, Schimmoller, Frauke, Wilson, Timothy R., Friedman, Lori S., Cantley, Lewis C., Scaltriti, Maurizio, Baselga, José
Publicado en Science (2019)

REV7 counteracts DNA double-strand break resection and impacts PARP inhibition

por Xu, Guotai, Chapman, J. Ross, Brandsma, Inger, Yuan, Jingsong, Mistrik, Martin, Bouwman, Peter, Bartkova, Jirina, Gogola, Ewa, Warmerdam, Daniël, Barazas, Marco, Jaspers, Janneke E., Watanabe, Kenji, Pieterse, Mark, Kersbergen, Ariena, Sol, Wendy, Celie, Patrick H. N., Schouten, Philip C., van den Broek, Bram, Salman, Ahmed, Nieuwland, Marja, de Rink, Iris, de Ronde, Jorma, Jalink, Kees, Boulton, Simon J., Chen, Junjie, van Gent, Dik C., Bartek, Jiri, Jonkers, Jos, Borst, Piet, Rottenberg, Sven
Publicado en Nature (2015)

ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer

por Xu, Guotai, Chhangawala, Sagar, Cocco, Emiliano, Razavi, Pedram, Cai, Yanyan, Otto, Jordan E, Ferrando, Lorenzo, Selenica, Pier, Ladewig, Erik, Chan, Carmen, Da Cruz Paula, Arnaud, Witkin, Matthew, Cheng, Yuanming, Park, Jane, Serna-Tamayo, Cristian, Zhao, HuiYong, Wu, Fan, Sallaku, Mirna, Qu, Xuan, Zhao, Alison, Collings, Clayton K, D’Avino, Andrew R., Jhaveri, Komal, Koche, Richard, Levine, Ross L., Reis-Filho, Jorge S., Kadoch, Cigall, Scaltriti, Maurizio, Leslie, Christina S., Baselga, José, Toska, Eneda
Publicado en Nat Genet (2020)

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

por Razavi, Pedram, Chang, Matthew T., Xu, Guotai, Bandlamudi, Chaitanya, Ross, Dara S., Vasan, Neil, Cai, Yanyan, Bielski, Craig M., Donoghue, Mark T.A., Jonsson, Philip, Penson, Alexander, Shen, Ronglai, Pareja, Fresia, Kundra, Ritika, Middha, Sumit, Cheng, Michael L., Zehir, Ahmet, Kandoth, Cyriac, Patel, Ruchi, Huberman, Kety, Smyth, Lillian M., Jhaveri, Komal, Modi, Shanu, Traina, Tiffany A., Dang, Chau, Zhang, Wen, Weigelt, Britta, Li, Bob T., Ladanyi, Marc, Hyman, David M., Schultz, Nikolaus, Robson, Mark E., Hudis, Clifford, Brogi, Edi, Viale, Agnes, Norton, Larry, Dickler, Maura N., Berger, Michael F., Iacobuzio-Donahue, Christine A., Chandarlapaty, Sarat, Scaltriti, Maurizio, Reis-Filho, Jorge S., Solit, David B., Taylor, Barry S., Baselga, José
Publicado en Cancer Cell (2018)