BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres

av Badie, Sophie, Carlos, Ana Rita, Folio, Cecilia, Okamoto, Keiji, Bouwman, Peter, Jonkers, Jos, Tarsounas, Madalena
I publikationen EMBO J (2015)

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres

av Badie, Sophie, Carlos, Ana Rita, Folio, Cecilia, Okamoto, Keiji, Bouwman, Peter, Jonkers, Jos, Tarsounas, Madalena
I publikationen EMBO J (2015)

Transcription factor Sp3 is essential for post-natal survival and late tooth development

av Bouwman, Peter, Göllner, Heike, Elsässer, Hans-Peter, Eckhoff, Gabriele, Karis, Alar, Grosveld, Frank, Philipsen, Sjaak, Suske, Guntram
Publicerad 2000

Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and for growth inhibition of breast cancer cells and cancer stem-like cells

av Pickholtz, Itay, Saadyan, Shira, Keshet, Gilmor I., Wang, Victor S., Cohen, Rachel, Bouwman, Peter, Jonkers, Jos, Byers, Stephen W., Papa, Moshe Z., Yarden, Ronit I.
I publikationen Oncotarget (2014)

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

av Sotiropoulou, Panagiota A., Karambelas, Andrea E., Debaugnies, Maud, Candi, Aurelie, Bouwman, Peter, Moers, Virginie, Revenco, Tatiana, Rocha, Ana Sofia, Sekiguchi, Kiyotoshi, Jonkers, Jos, Blanpain, Cedric
Publicerad 2013

Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds

av Duijndam, Britt, Goudriaan, Annabel, van den Hoorn, Tineke, van der Stel, Wanda, Le Dévédec, Sylvia, Bouwman, Peter, van der Laan, Jan Willem, van de Water, Bob
I publikationen Toxicol Sci (2021)

A high throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

av Evers, Bastiaan, Schut, Eva, van der Burg, Eline, Braumuller, Tanya M., Egan, David A., Holstege, Henne, Edser, Pauline, Adams, David J., Wade-Martins, Richard, Bouwman, Peter, Jonkers, Jos
Publicerad 2009

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

av Schoonen, Pepijn M., Talens, Francien, Stok, Colin, Gogola, Ewa, Heijink, Anne Margriet, Bouwman, Peter, Foijer, Floris, Tarsounas, Madalena, Blatter, Sohvi, Jonkers, Jos, Rottenberg, Sven, van Vugt, Marcel A. T. M.
I publikationen Nat Commun (2017)

BRCA2 Acts as RAD51 Loader to Facilitate Telomere Replication and Capping

av Badie, Sophie, Escandell, Jose M., Bouwman, Peter, Carlos, Ana Rita, Thanasoula, Maria, Gallardo, Maria M., Suram, Anitha, Jaco, Isabel, Benitez, Javier, Herbig, Utz, Blasco, Maria A., Jonkers, Jos, Tarsounas, Madalena
Publicerad 2010

Radiosensitivity is an acquired vulnerability of PARPi-resistant BRCA1-deficient tumors

av Barazas, Marco, Gasparini, Alessia, Huang, Yike, Küçükosmanoğlu, Asli, Annunziato, Stefano, Bouwman, Peter, Sol, Wendy, Kersbergen, Ariena, Proost, Natalie, de Korte-Grimmerink, Renske, van de Ven, Marieke, Jonkers, Jos, Borst, Gerben R., Rottenberg, Sven
I publikationen Cancer Res (2018)

Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation

av Monteiro, Alvaro N., Bouwman, Peter, Kousholt, Arne Nedergaard, Eccles, Diana M., Millot, Gael A., Masson, Jean-Yves, Schmidt, Marjanka K., Sharan, Shyam K., Scully, Ralph, Wiesmüller, Lisa, Couch, Fergus J., Vreeswijk, Maaike P.G.
I publikationen J Med Genet (2020)

Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

av van Meeteren, Laurens A., Ruurs, Paula, Stortelers, Catelijne, Bouwman, Peter, van Rooijen, Marga A., Pradère, Jean Philippe, Pettit, Trevor R., Wakelam, Michael J. O., Saulnier-Blache, Jean Sébastien, Mummery, Christine L., Moolenaar, Wouter H., Jonkers, Jos
Publicerad 2006

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

av Bowman-Colin, Christian, Xia, Bing, Bunting, Samuel, Klijn, Christiaan, Drost, Rinske, Bouwman, Peter, Fineman, Laura, Chen, Xixi, Culhane, Aedin C., Cai, Hong, Rodig, Scott J., Bronson, Roderick T., Jonkers, Jos, Nussenzweig, Andre, Kanellopoulou, Chryssa, Livingston, David M.
Publicerad 2013

PARP inhibitor efficacy depends on CD8+ T cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer

av Pantelidou, Constantia, Sonzogni, Olmo, De Oliveria Taveira, Mateus, Mehta, Anita K., Kothari, Aditi, Wang, Dan, Visal, Tanvi, Li, Michelle K., Pinto, Jocelin, Castrillon, Jessica A., Cheney, Emily M., Bouwman, Peter, Jonkers, Jos, Rottenberg, Sven, Guerriero, Jennifer L., Wulf, Gerburg M., Shapiro, Geoffrey I.
I publikationen Cancer Discov (2019)

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

av Bouwman, Peter, Aly, Amal, Escandell, Jose M., Pieterse, Mark, Bartkova, Jirina, van der Gulden, Hanneke, Hiddingh, Sanne, Thanasoula, Maria, Kulkarni, Atul, Yang, Qifeng, Haffty, Bruce G., Tommiska, Johanna, Blomqvist, Carl, Drapkin, Ronny, Adams, David J., Nevanlinna, Heli, Bartek, Jiri, Tarsounas, Madalena, Ganesan, Shridar, Jonkers, Jos
Publicerad 2010

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

av Tacconi, Eliana MC, Lai, Xianning, Folio, Cecilia, Porru, Manuela, Zonderland, Gijs, Badie, Sophie, Michl, Johanna, Sechi, Irene, Rogier, Mélanie, Matía García, Verónica, Batra, Ankita Sati, Rueda, Oscar M, Bouwman, Peter, Jonkers, Jos, Ryan, Anderson, Reina‐San‐Martin, Bernardo, Hui, Joannie, Tang, Nelson, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena
I publikationen EMBO Mol Med (2017)

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

av Gorrini, Chiara, Baniasadi, Pegah S., Harris, Isaac S., Silvester, Jennifer, Inoue, Satoshi, Snow, Bryan, Joshi, Purna A., Wakeham, Andrew, Molyneux, Sam D., Martin, Bernard, Bouwman, Peter, Cescon, David W., Elia, Andrew J., Winterton-Perks, Zoe, Cruickshank, Jennifer, Brenner, Dirk, Tseng, Alan, Musgrave, Melinda, Berman, Hal K., Khokha, Rama, Jonkers, Jos, Mak, Tak W., Gauthier, Mona L.
Publicerad 2013

A BRCA1 coiled-coil domain variant disrupting PALB2 interaction promotes the development of mammary tumors and confers a targetable defect in homologous recombination repair

av Pulver, Emilia M., Mukherjee, Chirantani, van de Kamp, Gerarda, Roobol, Stefan J., Rother, Magdalena B., van der Gulden, Hanneke, de Bruijn, Roebi, Lattanzio, Maria Valeria, van der Burg, Eline, Drenth, Anne Paulien, Verkaik, Nicole S., Hahn, Kerstin, Klarenbeek, Sjoerd, de Korte-Grimmerink, Renske, van de Ven, Marieke, Pritchard, Colin E.J., Huijbers, Ivo J., Xia, Bing, van Gent, Dik C., Essers, Jeroen, van Attikum, Haico, Chaudhuri, Arnab Ray, Bouwman, Peter, Jonkers, Jos
I publikationen Cancer Res (2021)

REV7 counteracts DNA double-strand break resection and impacts PARP inhibition

av Xu, Guotai, Chapman, J. Ross, Brandsma, Inger, Yuan, Jingsong, Mistrik, Martin, Bouwman, Peter, Bartkova, Jirina, Gogola, Ewa, Warmerdam, Daniël, Barazas, Marco, Jaspers, Janneke E., Watanabe, Kenji, Pieterse, Mark, Kersbergen, Ariena, Sol, Wendy, Celie, Patrick H. N., Schouten, Philip C., van den Broek, Bram, Salman, Ahmed, Nieuwland, Marja, de Rink, Iris, de Ronde, Jorma, Jalink, Kees, Boulton, Simon J., Chen, Junjie, van Gent, Dik C., Bartek, Jiri, Jonkers, Jos, Borst, Piet, Rottenberg, Sven
I publikationen Nature (2015)

BRCA1(185delAG) tumors may acquire therapy resistance through expression of RING-less BRCA1

av Drost, Rinske, Dhillon, Kiranjit K., van der Gulden, Hanneke, van der Heijden, Ingrid, Brandsma, Inger, Cruz, Cristina, Chondronasiou, Dafni, Castroviejo-Bermejo, Marta, Boon, Ute, Schut, Eva, van der Burg, Eline, Wientjens, Ellen, Pieterse, Mark, Klijn, Christiaan, Klarenbeek, Sjoerd, Loayza-Puch, Fabricio, Elkon, Ran, van Deemter, Liesbeth, Rottenberg, Sven, van de Ven, Marieke, Dekkers, Dick H.W., Demmers, Jeroen A.A., van Gent, Dik C., Agami, Reuven, Balmaña, Judith, Serra, Violeta, Taniguchi, Toshiyasu, Bouwman, Peter, Jonkers, Jos
I publikationen J Clin Invest (2016)