Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

Germ-line mutations in PALB2 lead to a familial predisposition to breast and pancreatic cancer or to Fanconi Anemia subtype N. PALB2 performs its tumor suppressor role, at least in part, by supporting homologous recombination-type double strand break repair (HR-DSBR) through physical interactions wi...

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Библиографические подробности
Главные авторы: Bowman-Colin, Christian, Xia, Bing, Bunting, Samuel, Klijn, Christiaan, Drost, Rinske, Bouwman, Peter, Fineman, Laura, Chen, Xixi, Culhane, Aedin C., Cai, Hong, Rodig, Scott J., Bronson, Roderick T., Jonkers, Jos, Nussenzweig, Andre, Kanellopoulou, Chryssa, Livingston, David M.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2013
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666744/
https://ncbi.nlm.nih.gov/pubmed/23657012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305362110
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