Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development

Inherited mutations in BRCA1, BRCA2, and PALB2 cause a high risk of breast cancer. Here, we conducted parallel conditional knockout (CKO) of Brca1, Palb2, and Brca2, individually and in combination, along with one copy of Trp53, in the mammary gland of nulliparous female mice. We observed a function...

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Detalhes bibliográficos
Publicado no:NPJ Breast Cancer
Main Authors: Huo, Yanying, Selenica, Pier, Mahdi, Amar H., Pareja, Fresia, Kyker-Snowman, Kelly, Chen, Ying, Kumar, Rahul, Da Cruz Paula, Arnaud, Basili, Thais, Brown, David N., Pei, Xin, Riaz, Nadeem, Tan, Yongmei, Huang, Yu-Xiu, Li, Tao, Barnard, Nicola J., Reis-Filho, Jorge S., Weigelt, Britta, Xia, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065161/
https://ncbi.nlm.nih.gov/pubmed/33893322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-021-00253-5
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