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Evidence of inter-tissue differences in the DNA damage response and the pro-oncogenic role of NFκB in mice with disengaged BRCA1-PALB2 interaction

The BRCA1-PALB2-BRCA2 axis plays an essential role in DNA homologous recombination repair (HRR), defect in which drives genome instability and cancer development. How cells with defects in this pathway respond to DNA damage in vivo and how tumors develop from these cells remain poorly defined. Here...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Mahdi, Amar Hekmat, Huo, Yanying, Tan, Yongmei, Simhadri, Srilatha, Vincelli, Gabriele, Gao, Jie, Ganesan, Shridar, Xia, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050088/
https://ncbi.nlm.nih.gov/pubmed/29739757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0388
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