Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development

Inherited mutations in BRCA1, BRCA2, and PALB2 cause a high risk of breast cancer. Here, we conducted parallel conditional knockout (CKO) of Brca1, Palb2, and Brca2, individually and in combination, along with one copy of Trp53, in the mammary gland of nulliparous female mice. We observed a function...

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Détails bibliographiques
Publié dans:NPJ Breast Cancer
Auteurs principaux: Huo, Yanying, Selenica, Pier, Mahdi, Amar H., Pareja, Fresia, Kyker-Snowman, Kelly, Chen, Ying, Kumar, Rahul, Da Cruz Paula, Arnaud, Basili, Thais, Brown, David N., Pei, Xin, Riaz, Nadeem, Tan, Yongmei, Huang, Yu-Xiu, Li, Tao, Barnard, Nicola J., Reis-Filho, Jorge S., Weigelt, Britta, Xia, Bing
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065161/
https://ncbi.nlm.nih.gov/pubmed/33893322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-021-00253-5
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