Patient-derived xenografts: a relevant preclinical model for drug development

by Pompili, Luca, Porru, Manuela, Caruso, Carla, Biroccio, Annamaria, Leonetti, Carlo
Published in J Exp Clin Cancer Res (2016)

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

by Porru, Manuela, Pompili, Luca, Caruso, Carla, Biroccio, Annamaria, Leonetti, Carlo
Published in J Exp Clin Cancer Res (2018)

Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer

by Porru, Manuela, Zizza, Pasquale, Panera, Nadia, Alisi, Anna, Biroccio, Annamaria, Leonetti, Carlo
Published in Cancers (Basel) (2020)

Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid

by Misso, Gabriella, Porru, Manuela, Stoppacciaro, Antonella, Castellano, Maria, De Cicco, Federica, Leonetti, Carlo, Santini, Daniele, Caraglia, Michele
Published 2012

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

by Rizzo, Angela, Iachettini, Sara, Zizza, Pasquale, Cingolani, Chiara, Porru, Manuela, Artuso, Simona, Stevens, Malcolm, Hummersone, Marc, Biroccio, Annamaria, Salvati, Erica, Leonetti, Carlo
Published 2014

Erratum: Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

by Rizzo, Angela, Iachettini, Sara, Zizza, Pasquale, Cingolani, Chiara, Porru, Manuela, Artuso, Simona, Stevens, Malcolm, Hummersone, Marc, Biroccio, Annamaria, Salvati, Erica, Leonetti, Carlo
Published in J Exp Clin Cancer Res (2015)

Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance

by Giarra, Simona, Zappavigna, Silvia, Campani, Virginia, Abate, Marianna, Cossu, Alessia Maria, Leonetti, Carlo, Porru, Manuela, Mayol, Laura, Caraglia, Michele, De Rosa, Giuseppe
Published in Pharmaceutics (2018)

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

by Rizzo, Angela, Salvati, Erica, Porru, Manuela, D’Angelo, Carmen, Stevens, Malcolm F., D’Incalci, Maurizio, Leonetti, Carlo, Gilson, Eric, Zupi, Gabriella, Biroccio, Annamaria
Published 2009

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

by Garufi, Alessia, Trisciuoglio, Daniela, Porru, Manuela, Leonetti, Carlo, Stoppacciaro, Antonella, D’Orazi, Valerio, Avantaggiati, Maria Laura, Crispini, Alessandra, Pucci, Daniela, D’Orazi, Gabriella
Published 2013

Adipose-derived stem cell-mediated paclitaxel delivery inhibits breast cancer growth

by Scioli, Maria Giovanna, Artuso, Simona, D'Angelo, Carmen, Porru, Manuela, D’Amico, Federico, Bielli, Alessandra, Gentile, Pietro, Cervelli, Valerio, Leonetti, Carlo, Orlandi, Augusto
Published in PLoS One (2018)

Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid

by Porru, Manuela, Zappavigna, Silvia, Salzano, Giuseppina, Luce, Amalia, Stoppacciaro, Antonella, Balestrieri, Maria Luisa, Artuso, Simona, Lusa, Sara, De Rosa, Giuseppe, Leonetti, Carlo, Caraglia, Michele
Published in Oncotarget (2014)

Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

by Nardinocchi, Lavinia, Pantisano, Valentina, Puca, Rosa, Porru, Manuela, Aiello, Aurora, Grasselli, Annalisa, Leonetti, Carlo, Safran, Michal, Rechavi, Gideon, Givol, David, Farsetti, Antonella, D'Orazi, Gabriella
Published 2010

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

by Salvati, Erica, Rizzo, Angela, Iachettini, Sara, Zizza, Pasquale, Cingolani, Chiara, D'Angelo, Carmen, Porru, Manuela, Mondello, Chiara, Aiello, Aurora, Farsetti, Antonella, Gilson, Eric, Leonetti, Carlo, Biroccio, Annamaria
Published in Nucleic Acids Res (2015)

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

by Reisländer, Timo, Lombardi, Emilia Puig, Groelly, Florian J., Miar, Ana, Porru, Manuela, Di Vito, Serena, Wright, Benjamin, Lockstone, Helen, Biroccio, Annamaria, Harris, Adrian, Londoño-Vallejo, Arturo, Tarsounas, Madalena
Published in Nat Commun (2019)

Effect of Small Molecules Modulating Androgen Receptor (SARMs) in Human Prostate Cancer Models

by Tesei, Anna, Leonetti, Carlo, Di Donato, Marzia, Gabucci, Elisa, Porru, Manuela, Varchi, Greta, Guerrini, Andrea, Amadori, Dino, Arienti, Chiara, Pignatta, Sara, Paganelli, Giulia, Caraglia, Michele, Castoria, Gabriella, Zoli, Wainer
Published 2013

Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion

by Amendola, Donatella, Nardella, Marta, Guglielmi, Loredana, Cerquetti, Lidia, Carico, Elisabetta, Alesi, Viola, Porru, Manuela, Leonetti, Carlo, Bearzi, Claudia, Rizzi, Roberto, D’Agnano, Igea, Stigliano, Antonio, Novelli, Giuseppe, Bucci, Barbara
Published 2014

Sema6A and Mical1 control cell growth and survival of BRAF(V600E) human melanoma cells

by Loria, Rossella, Bon, Giulia, Perotti, Valentina, Gallo, Enzo, Bersani, Ilaria, Baldassari, Paola, Porru, Manuela, Leonetti, Carlo, Di Carlo, Selene, Visca, Paolo, Brizzi, Maria Felice, Anichini, Andrea, Mortarini, Roberta, Falcioni, Rita
Published in Oncotarget (2014)

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

by Zizza, Pasquale, Cingolani, Chiara, Artuso, Simona, Salvati, Erica, Rizzo, Angela, D'Angelo, Carmen, Porru, Manuela, Pagano, Bruno, Amato, Jussara, Randazzo, Antonio, Novellino, Ettore, Stoppacciaro, Antonella, Gilson, Eric, Stassi, Giorgio, Leonetti, Carlo, Biroccio, Annamaria
Published in Nucleic Acids Res (2016)

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

by Salvati, Erica, Zizza, Pasquale, Rizzo, Angela, Iachettini, Sara, Cingolani, Chiara, D’Angelo, Carmen, Porru, Manuela, Randazzo, Antonio, Pagano, Bruno, Novellino, Ettore, Pisanu, Maria Elena, Stoppacciaro, Antonella, Spinella, Francesca, Bagnato, Anna, Gilson, Eric, Leonetti, Carlo, Biroccio, Annamaria
Published 2014

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

by Zimmer, Jutta, Tacconi, Eliana M.C., Folio, Cecilia, Badie, Sophie, Porru, Manuela, Klare, Kerstin, Tumiati, Manuela, Markkanen, Enni, Halder, Swagata, Ryan, Anderson, Jackson, Stephen P., Ramadan, Kristijan, Kuznetsov, Sergey G., Biroccio, Annamaria, Sale, Julian E., Tarsounas, Madalena
Published in Mol Cell (2016)