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BRCA2 Acts as RAD51 Loader to Facilitate Telomere Replication and Capping
BRCA2 is a key component of the homologous recombination (HR) pathway of DNA repair, acting as the loader of RAD51 recombinase at sites of double-strand breaks. Here, we demonstrate that BRCA2 associates with telomeres during S/G2 and facilitates RAD51 loading onto telomeres. Conditional Brca2 delet...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2998174/ https://ncbi.nlm.nih.gov/pubmed/21076401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1943 |
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