BRCA2 Acts as RAD51 Loader to Facilitate Telomere Replication and Capping

BRCA2 is a key component of the homologous recombination (HR) pathway of DNA repair, acting as the loader of RAD51 recombinase at sites of double-strand breaks. Here, we demonstrate that BRCA2 associates with telomeres during S/G2 and facilitates RAD51 loading onto telomeres. Conditional Brca2 delet...

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Détails bibliographiques
Auteurs principaux: Badie, Sophie, Escandell, Jose M., Bouwman, Peter, Carlos, Ana Rita, Thanasoula, Maria, Gallardo, Maria M., Suram, Anitha, Jaco, Isabel, Benitez, Javier, Herbig, Utz, Blasco, Maria A., Jonkers, Jos, Tarsounas, Madalena
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998174/
https://ncbi.nlm.nih.gov/pubmed/21076401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1943
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