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BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres
Loss of telomere protection occurs during physiological cell senescence and ageing, due to attrition of telomeric repeats and insufficient retention of the telomere-binding factor TRF2. Subsequently formed telomere fusions trigger rampant genomic instability leading to cell death or tumorigenesis. M...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4339125/ https://ncbi.nlm.nih.gov/pubmed/25582120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488947 |
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