BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

Homologous recombination plays a key role in the repair of double-strand breaks (DSBs), and thereby significantly contributes to cellular tolerance to radiotherapy and some chemotherapy. DSB repair by homologous recombination is initiated by 5’ to 3’ strand resection (DSB resection), with nucleases...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hoa, Nguyen Ngoc, Kobayashi, Junya, Omura, Masato, Hirakawa, Mayumi, Yang, Soo-Hyun, Komatsu, Kenshi, Paull, Tanya T., Takeda, Shunichi, Sasanuma, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409214/
https://ncbi.nlm.nih.gov/pubmed/25909997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124495
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