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CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
Topoisomerases class II (topoII) cleave and re-ligate the DNA double helix to allow the passage of an intact DNA strand through it. Chemotherapeutic drugs such as etoposide target topoII, interfere with the normal enzymatic cleavage/re-ligation reaction and create a DNA double-strand break (DSB) wit...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064790/ https://ncbi.nlm.nih.gov/pubmed/21087997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1175 |
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