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CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
Topoisomerases class II (topoII) cleave and re-ligate the DNA double helix to allow the passage of an intact DNA strand through it. Chemotherapeutic drugs such as etoposide target topoII, interfere with the normal enzymatic cleavage/re-ligation reaction and create a DNA double-strand break (DSB) wit...
में बचाया:
| मुख्य लेखकों: | , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064790/ https://ncbi.nlm.nih.gov/pubmed/21087997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1175 |
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