CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1

Topoisomerases class II (topoII) cleave and re-ligate the DNA double helix to allow the passage of an intact DNA strand through it. Chemotherapeutic drugs such as etoposide target topoII, interfere with the normal enzymatic cleavage/re-ligation reaction and create a DNA double-strand break (DSB) wit...

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Bibliographic Details
Main Authors: Quennet, Verena, Beucher, Andrea, Barton, Olivia, Takeda, Shunichi, Löbrich, Markus
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064790/
https://ncbi.nlm.nih.gov/pubmed/21087997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1175
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