CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks

The pleiotropic CCCTC-binding factor (CTCF) plays a role in homologous recombination (HR) repair of DNA double-strand breaks (DSBs). However, the precise mechanistic role of CTCF in HR remains largely unclear. Here, we show that CTCF engages in DNA end resection, which is the initial, crucial step i...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Hwang, Soon Young, Kang, Mi Ae, Baik, Chul Joon, Lee, Yejin, Hang, Ngo Thanh, Kim, Byung-Gyu, Han, Joo Seok, Jeong, Jae-Hoon, Park, Daechan, Myung, Kyungjae, Lee, Jong-Soo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753481/
https://ncbi.nlm.nih.gov/pubmed/31340001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz639
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